Chapter 330 New clinical guidelines, the rise of naproxen!
Xu Qiu's eyes were burning, but his tone was calm and calm, and said:
"Clinically, what should I do when facing a patient with advanced cancer that needs surgery and chemotherapy as soon as possible, but recurrent fever?"
The doctors were silent for a while.
This type of patient has always been the most troublesome type on the front line.
In the case of continuous fever, the risk of surgery or chemotherapy is extremely high.
In this dilemma, many times, doctors can only take the chance and choose the safest plan for treatment after weighing the pros and cons.
As for whether it is the most suitable, no one knows.
After all, side effects, sequelae, etc. are not very important in the face of life. The most important thing is to lower the temperature and complete the surgery and chemotherapy.
In the conference room, Xu Qiu paused for a few seconds and gave the answer directly.
"In addition to conventional cooling methods, the naproxen drug may be a new clue."
During the meeting, Xu Qiu shared the screen.
An experiment is recorded above.ъìqυgΕtv.℃ǒΜ
"Naproxen experiment."
Xu Qiu briefly introduced it.
In 1984, a doctor named changjc accidentally discovered that 15 patients with malignant fever took naproxen orally, 14 of them quickly cooled down, and their body temperature did not rebound during the medication. In contrast, the other five patients with fever due to infection also took naproxen, but none of them lowered their fever.
Since then, Naproxen has gained a reputation as a "cancer heat nemesis" in a small range, and some unfamous documents have appeared in the industry.
It was not until 1995 that a gynecologist in the country of Berry Country determined that naproxen had an extremely strong antipyretic effect on cancerous fever in gynecological malignant tumors, and published a SCI paper. Naproxen's symptomatic treatment of cancerous fever was confirmed.
In 2005, the naproxen experiment began.
That is, the experimenter took 375mg of naproxen capsules orally each time, twice a day for three days. After taking the medicine, the body temperature of the cancerous fever quickly returned to normal, and the mental state of lethargy was also improved.
Since then, the new indications for naproxen have been confirmed.
Unfortunately, no matter how professional the paper is or how shocking the conclusions are, it is possible to be buried in the vast sea of documents.
Although naproxen is good, it is only good for clinicians and patients.
What money can you make at a price of a box of a few dollars?
Medicine is not a paradise, and interests and capital are also interfering in this field.
When monopolizing abroad, we rely on patent fees, usage fees and technical barriers to make money.
Take the cardiovascular department where Linhai small-caliber vascular is located for example. In the past, Maikovi and Termau completely controlled the domestic artificial vascular market. When it was most scarce, there were only one or two artificial vascular cells in the hospital.
In addition to blood vessels, as small as Johnson & Johnson's prolene surgical sutures, Gore's gore-tex sutures, pacemakers and ecmo, these high-end equipment are all tightly held back by foreign countries, just like the chip field.
Naproxen, a few dollars worth of old medicine, technology, patents, etc. from fifty or sixty years ago, has long been completely disclosed.
If it is widely used in clinical practice, it will have an extremely huge impact on foreign pharmaceutical companies in the industry, and the market for losses will be difficult to estimate.
Therefore, until now, although naproxen is known as the "cancer heat nemesis", it has been firmly pressed into those few pages of the literature and is difficult to be known.
Even Xu Qiu, if he had not met many patients with recurrent fever and had basically read all the documents related to the "cause of fever" in human history, he would not have known that there was a strange medicine like naproxen.
...
"I have summarized that it has two major significance for naproxen to be included in the clinical practice.
1. It can avoid the ineffective use of antibiotics and reduce the pain and damage caused by repeated infection-related examinations to patients.
On the other hand, it is also the most important point. Early use of naproxen can avoid delays in the treatment of malignant tumors!”
After more than an hour of lecture, Xu Qiu gave this last suggestion.
In the conference room, everyone in the Oncology Department of Linhai First Hospital applauded excitedly.
All over the country, colleagues who were watching this online lecture were shocked and inexplicably excited.
Naproxen!
There are many tumor patients who have repeated and continuous fever in various hospitals, but are ineffective against infection and anti-allergic drugs.
The naproxen mentioned in this lecture gave many oncologists ideas!
The Great Xia is too big, not only Union, nor only Three A, but also Xu Qiu.
There are also too many community hospitals and grassroots hospitals that also treat tumor patients.
They were helpless and worried when facing the patient's strange fever, and Xu Qiu's lecture gave them a new diagnosis direction!
Dingdong—
Ten minutes after the lecture, an article was posted on the entire network through Xu Qiu’s personal accounts on each platform.
"Naproxen, a 4.8-yuan drug!"
The first sentence of the opening sentence, "The pathogenesis of cancerous fever has not been clarified yet. Similarly, no one knows the pharmacological mechanism of naproxen to fight cancerous fever", which made countless colleagues and netizens sigh in their hearts.
"However, countless clinical trials and literature have shown that its efficacy on fever caused by tumors is very significant, the cooling effect is fast, and the chance of rebound is extremely low!"
And this second sentence made countless people's eyes lit up and excited.
After a two-thousand-word popular science article, Xu Qiu summarized the tumor range mentioned in the lecture and applicable to naproxen.
In fact, it is the list of tumors that are prone to cancer fever.
These include "giant lymph node hyperplasia, Hodgkin's lymphoma and non-Hodgkin's lymphoma, kidney cancer, liver cancer and ovarian cancer" and so on.
Repeated fever in these tumor patients is the best indicator for the use of naproxen.
It is a standard answer for the somewhat confused colleagues and patients.
In addition, the influence brought by Xu Qiu this lecture has exceeded the limit of popular science.
The main reason is that both in the industry and in the province have a high degree of trust in Xu Qiu himself.
Therefore, after consulting and confirming with Xu Qiu, Baiyun Province directly purchased with volume and started price negotiations with naproxen manufacturers.
The further price was finally determined, from 4.8 yuan to 4.29 yuan. Since then, Baiyun Province has launched collective procurement of the drug and distributed it to pharmacies of major hospitals in the province as needed.
And some places outside the province are still waiting and watching.
A few days later, the official official account of a second-level hospital in Sichuan Province issued a document:
"A 47-year-old female patient in our hospital started to have repeated fever on the third day of hospitalization after a puncture biopsy was confirmed by ovarian adenocarcinoma.
Moxifloxacin anti-infection treatment was taken on the same day, and the treatment did not improve for six days;
The subsequent upgrade of antibiotics still fails.
Because the patient has advanced ovarian cancer, surgery and chemotherapy are urgent, and the hospital consultations are helpless against fever and can only try to take the risk of chemotherapy.
At a critical moment, our hospital accidentally saw the naproxen mentioned by Dr. Xu Qiu in the lecture. He immediately asked his family to buy it and take the medicine immediately. After three hours, the patient's body temperature and heart rate returned to normal!
Thanks to Dr. Xu Qiu for his selfless guidance. Naproxen is indeed a cancer fever nemesis!”
This is just the beginning.
Chapter completed!