Chapter 174 Human Experiment
The Spark Life Sciences Institute officially launched a human experiment on inducibles.
The AIDS project researchers began to take the volunteers away according to the process formulated by Director Wang Xiaoxiao.
Wang Xiaoxiao stared at the experimental situation of various researchers and solved possible problems at any time.
72 hours have passed since the volunteers injected inducibles, and each project team has developed steadily, and no death has occurred.
Wang Xiaoxiao felt relieved. The use of inducible substances can be basically considered safe. As long as it can achieve a certain therapeutic effect, the AIDS project can be officially ended.
He first walked to the laboratory of researcher Ma Pingfang.
Ma Pingfang is all normal and healthy people here. It is mainly observed whether inducibles can exist in healthy people for a long time and will not cause acute failure of the organs.
As long as the inducer does not cause rapid failure of human organs like deadly poisons, even if some side effects are produced, it can be made into a drug for treating AIDS.
Compared with the threat of AIDS to health, it causes certain levels of liver and kidney damage, or symptoms such as persistent low fever, high blood pressure, etc.
It can be completely controlled through current medical means, and these side effects are much less effective than other AIDS treatment agents.
When Ma Pingfang saw Wang Xiaoxiao coming to his laboratory, she looked a little cramped and said respectfully: "Director Wang, you are here, it's basically normal here."
Wang Xiaoxiao saw that the volunteers were all in the laboratory, and they were not lying on the hospital bed. They were curious to use the VR smart glasses provided by the laboratory to experience the virtual world. Some were talking to their families.
Everyone's face is full of healthy rosy, and no one shows organ failure.
Wang Xiaoxiao said with satisfaction: "Old Ma, let me introduce your situation here."
Ma Pingfang's tone was clear, and the key points were extracted. Reported: "Director Wang, I will conduct a muscle allergy experiment before injecting inducibles into the volunteers.
It was discovered that the human immune system did not respond too strongly to it, so it began to formally inject inducibles into volunteers.
Begin injecting a very small amount of 0.05 mg, and draw the volunteer's blood every half an hour to test his immune system and various indicators.
The volunteers found no abnormalities, and I started to inject exactly half of the dose of 0.5 mg.
After a period of observation, it was found that the lymph nodes were enlarged, lymph B cells showed abnormal differentiation, and lymph T cells became very active, but the volunteers still did not have much abnormal reaction.
This morning, the third injection of inducible was given, and I was given a normal treatment dose of 1 mg.
It has been observed for three hours now. In addition to the more active immune system, the spleen is a little enlarged and no abnormalities are found.
Now it can only be determined that inducers will not cause the excitement of the immune system and will attack the normal cells of the human being at will.
Inducin is not hepatotoxic or nephrotoxic, and neither the liver nor the kidneys have abnormal changes.
Through our observation, inducers can exist in human blood and lymph for a long time, and the metabolic cycle is about 13 months."
When Wang Xiaoxiao listened to Ma Pingfang's report, he kept nodding. This situation was similar to what he had predicted.
Human experiments of normal people have proved that his inference before the experiment has caused almost no harm to normal people.
He is a biological scientist, not an executioner, and he is not sure and will not apply for human experiments.
Wang Xiaoxiao could not guarantee that there was no problem with the induction element before, after all, the human body is a complex biological system.
Modern medicine has not yet analyzed the specific components of blood, and inducers may not be able to react with certain unknown components in the blood. Fortunately, this very difficult problem has not occurred.
"Old Ma, you continue to observe and always pay attention to the changes in peripheral immune organs such as spleen and lymph nodes.
Try to increase the dose within the safe range and collect the maximum dose used inducibles under safe conditions." Wang Xiaoxiao solemnly explained.
He came to Wu Minzhe's laboratory again, where he was responsible for HIV carriers.
As soon as Wang Xiaoxiao walked into the laboratory, she encountered pairs of longing eyes.
After someone saw him come in, he boldly asked him questions.
"Director Wang, can you really treat AIDS?"
"Director Wang, I don't want your test costs. Can you clear the HIV on me?"
"Director Wang, I always feel that I am dying. I take care of myself like a porcelain doll every day, for fear that the virus will invade and the immune system will not be able to kill it."
Wang Xiaoxiao said in a gentle tone: "You can calm down. After the experiment is officially over, we will inform you of the relevant situation."
He saw that Wu Minzhe was also appeaseing these volunteers, so he called Wu Minzhe out of the laboratory to find out the specific situation from him.
Wu Minzhe immediately reported: "Director Wang, we first conducted a small dose experiment and found that the immune system seemed to be under command. It was originally lymphatic T cells to deal with HIV.
With the participation of inducibles, macrophages and lymphoblast B cells also proliferate and differentiate rapidly.
Macrophages began to eliminate HIV, and lymph B cells quickly differentiate into plasma cells, producing a large number of antibodies to eliminate the free HIV virus in the body fluid.
At the same time, the proliferation and differentiation rate of lymphatic T cells increases exponentially. The larger the dose of inducer, the faster the growth rate of lymphatic T cells.
Only 72 hours have passed, the HIV virus in these volunteers has been cleaned up by 28% to 37%, and the speed of cleaning is related to the function of the individual's immune system.
When injecting inducible hormone, volunteers will experience signs of systemic low fever and increased blood pressure.
If too much inducer is used, the immune system synthesizes cells too quickly, and related symptoms such as low blood oxygen and blood sugar, lack of amino acids will occur.
As HIV is eliminated in large quantities, precipitates will also block blood vessels and cause local thrombosis.
The human immune system cannot cope with bacteria and viruses in the body, and other viruses reproduce at high speed.”
Wang Xiaoxiao smiled and said with satisfaction: "It seems that the induction substance is very successful. The data you collected is very good. Keep up with the effort and observe the changes in the spleen and lymph nodes of peripheral immune organs."
He finally came to Qi Zhenyue's laboratory, where she was responsible for volunteers who were already suffering from AIDS.
As soon as Wang Xiaoxiao walked into the laboratory, she heard volunteers constantly begging.
"Doctor Qi, do your medicine work? Am I almost dead?"
"Doctor Qi, I feel that I am no longer able to do it. This is a confusion and fever, nausea and vomiting. Is it because your medicine has too many side effects?"
"Xiao Qi, your medicine is so good. I always feel a little drowsy. After using your medicine, I found that the symptoms are much better."
Wang Xiaoxiao didn't want to experience the situation he was watched just now, so he immediately called Qi Zhenyue out to learn about the situation of inducing the induced suscept for AIDS patients.
"I heard the patient's words that our inducible hormones have a strong therapeutic effect on AIDS patients." Wang Xiaoxiao said with a more affirmative tone.
Qi Zhenyue smiled bitterly and shook her head helplessly: "Director Wang, our induction can play a certain role in AIDS patients. If the human immune system is not damaged too seriously by the HIV virus.
Inducers can stimulate the rapid proliferation and differentiation of mature immune cells in lymph nodes and spleen, and control the condition of AIDS.
Through my observation, as long as the medication is taken with caution, AIDS patients may be cured, making them a long-term virus carrier.
But if the immune system has collapsed, the number of mature immune cells in the spleen and lymph nodes is very small.
This will only stimulate the spleen and lymph nodes, overdraw the vitality of immune organs, and cause temporary improvement of the immune system function, but will not curb the development of AIDS."
"You continue to observe these data, especially for patients with very serious AIDS. I have now had basic ideas and will adjust the experimental plan later." Wang Xiaoxiao said with a serious expression.
He has basically understood the situation of inducible hormones in the human body.
After Wang Xiaoxiao returned to the office, he began to adjust the volunteers' next experiment direction based on human experimental data. Based on the human experimental data, he and Mo Zi cooperated to adjust the volunteers' next experiment direction.
Chapter completed!