After a long period of silence, the laboratory of Qingzhu Chemical, with the strong help of the medical research team set up by the Guwen Association, launched an epoch-making bomb, that is, the sterilization special drug "sulfonamide"

This drug was not used in medicine at the beginning. When Yi Zhongming first started to own the Qingzhu Chemical Company, Zhong Yang secretly discussed this substance with him. In this way, Yi Zhongming began to study various chemical dyes in detail and repeatedly.

In fact, at the beginning, a German chemist synthesized a red dye. Because it contains some sterilizing ingredients, it was used sporadically to treat diseases such as erysipelas. However, in the experiment, it had no obvious bactericidal effect in the test tube, so it did not attract Yi Zhongming's attention.

Zhong Yang did not have much professional knowledge about the specific development process of this substance in history. He only roughly understood that sulfonamides are from some chemical dyes. Anyway, it is not harmful to try them. Even if they are not developed for a while, they can still achieve some results in textile printing and dyeing.

Until this year, in early February 1924, the biochemist Du Qisheng, a returning student, discovered during the experiment that this red dye had a high efficacy in mice infected with hemolytic streptococci. Later, he used rabbits and dogs to conduct experiments, and they were both successful.

Yi Zhongming was also quite clear about the results of the experiment, but because he did not dare to use people for experiments, he could not confirm whether this substance was the special drug "sulfonamide" mentioned by Zhong Yang. Du Qisheng was full of joy and named this drug "Loess".

This drug looks like a slightly yellow crystalline powder, so it gets the name "Loess". In terms of basic physical properties, it is prone to deterioration when it encounters light and the color gradually changes. From the chemical analysis, this drug has extremely low solubility in water and is more soluble in dilute alkali, but after forming sodium salt, it is easily soluble in water, and its aqueous solution is highly alkaline.

I thought I would have to conduct a long period of complex testing before I could really put it into the practical stage. But I didn’t expect that a sudden unexpected situation changed the emergence of “sulfonamide”.

Just at this moment, Du Qisheng's wife suffered from streptococcal septicemia and was dying. He was anxious and decided to use "Loess", and his wife was finally saved.

What is strange is that "loes" can only kill streptococci in the body, but not in the test tube. For this plan, all members of the Fifth Institute, which specializes in chemical research, concluded that "loes" must have become another thing that is effective for bacteria in the body.

So they began to analyze the active ingredients of "loes" and decompose "ammoniasulfonamide". In fact, someone synthesized this compound as early as 1908, but unfortunately its medical value was not discovered by people at that time. The name of sulfonamide quickly spread widely in the medical community.

And "Loess" was finally renamed "sulfonamide".

Before the advent of sulfonamide, Western medicine felt very difficult for inflammation, especially epidemic meningitis, pneumonia, sepsis, etc. because of the lack of specific medicines.

Zhong Yang also learned this exciting news from Yi Zhongming and ordered everyone to commend it. In particular, Du Qisheng, a genius scientist in chemistry, was able to become one of the core members of the Ancient Chinese Society and obtained the qualification to enter the sub-space.

Not only that, Du Qisheng put forward unique insights on the subsequent development of "sulfonamide" with amazing observation and professional knowledge. He believes that "sulfonamide" is not just a drug, but should cover a large category of drug systems. He also made some predictions for the detailed classification work in the future.

Qingzhu Chemical made "sulfapyridine" three years later, "sulfathiazole" was made in 1929, and "sulfadiazine" was made in 1932. In this way, doctors can choose drugs suitable for treating various infections from a "prosperous" "sulfa family". These are all later stories. The current situation is that Zhong Yang is finally holding a special drug patent that can control the situation. This is very important.

This chemical agent isolated from the red dye was tested on white mice and found that it had a strong bactericidal effect on streptococci infection. Shortly afterwards, the Fifth Institute conducted clinical trials with a British hospital in Guangzhou City, and found that this drug had a very high effect on pneumonia and heat production. After some chemical structure fine-tuning, it can have a significant killing effect on E. coli and Staphylococcus aureus, with significant effects.

The results and paper of this experiment caused a sensation in the world. Before this, there was no special drug in the world that could have a significant and powerful killing effect on these highly infectious bacteria. Countless people die every year from wound infection, especially Westerners. In an environment where there is no Chinese patent medicine available, even a cold and diarrhea can kill them.

For the formulation of this drug, Smith even came to Zhong Yang personally to discuss, representing more than just the embassy or a trivial branch of the British CIA in China. He brought the sincerity of the British Empire and wanted to participate in this drug development plan.

As for the results of clinical trials alone, many interested people have seen the huge benefits, not to mention the importance of establishing a good relationship with Tianyu Group, a rising new organization.

The British may be arrogant, but they are just incompetent politicians in Parliament, which does not mean that everyone is like this. They can dominate the world for more than a century, and British businessmen and intelligence workers are quite realistic. In their eyes, they only have interests, their own, and their own.

Take Smith for example. He also has the professional qualities of a national intelligence worker, but he also wants to enjoy his old age. Given the mistakes in Soviet intelligence in Inner Mongolia, he never wants to sit back to his original position in his life. Now, he cares more about how to make more money to maintain a decent life after retirement.

Partnering with Yi Zhongming to run high-end cosmetics has made his appetite wide. Greed is like endless **, burning his heart all the time. The huge benefits of medical products involved in "sulfonamide" have made him crazy. This kind of medicine means a chance to survive for patients, and he will buy it even if he loses everything.

The development of Western medicine is just beginning, but Westerners do not understand the way of health preservation, so there are big problems in their daily diet. They like foods with heavier tastes and rarely eat vegetables. As a result, various diseases occur frequently, especially diseases of the large intestine and stomach. They have never had a good solution for this chronic inflammation.

Moreover, there is no traditional Chinese medicine in the West to protect the lives and health of the people, so many people died because of this, and the doctors were reluctant to do so.

However, with the release of "sulfonamide", all these difficulties are solved. Although this medicine is not essential for China, it can also be used as a practical specialty drug in emergency situations. However, Yi Zhongming is currently concerned about the public sales of "sulfonamide", and believes that he should wait for a while before talking about it.

Yi Zhongming's move is indeed a mature and steady approach. He is not arrogant or impatient when encountering things. Try to follow the right path. He can be said to be a big shot.

Zhong Yang also has this meaning, it is related to human life and cannot be careless at all. Every Western medicine is launched on the market and must undergo strict theoretical certification and clinical testing. It will only be sold on the market until it is fully confirmed and can be used with confidence. At least in China, Zhong Yang does not intend to take care of foreign sales.

First of all, the first country to be sold on the public was the United Kingdom. This matter was left to Smith anyway, so Zhong Yang and Yi Zhongming were too lazy to care about it.

It took Du Qisheng six months to make this discovery and finally form a complete experimental paper, but it only took a short month to license the production and officially enter the ranks of drugs. People need it so much, even in the experimental stage, many patients who know that they have this special drug do not care about the dangers of being a guinea pig, and insist on using this unauthorized drug in the experimental stage.

This drug has caused an uproar in the Western world, especially in the Western medical community. Many people have doubts about this drug and want to boycott it. However, merchants seek profit, especially those Jewish capital chaebols who control the economy, instigated members of parliament to propose a proposal, and finally passed a parliamentary resolution and approved the listing of "sulfonamide".

Many people made a fortune because of this. Zhong Yang, Yi Zhongming, Du Qisheng, Smith, and other stakeholders stood in the high clouds and smiled and said nothing at the rolling wealth.

Seeing the popular sales scene, Zhong Yang actually sighed in his heart that "sulfonamide" is indeed very useful, but relatively speaking, it is also very harmful. The same Western medicine has different usages, which can also lead to serious consequences and even death. Therefore, the drug is launched in a hurry without strict review, which will inevitably bring great harm to the safety of people's lives and property.

However, the life and death of the British people is not something that Zhong Yang has to worry about. The great powers of this era are actually not much better than the people of their own country. There are countless random things, and at most they are one step ahead of our level around 2010.

You should know that Zhong Yang had used the finished "sulfonamide" medicine to analyze it in the smart factory. The Fifth Institute also conducted a lot of testing work. Gradually, he mastered the characteristics of some of these drugs and the use needs to be known. The power of the smart factory is that it can save a lot of complicated research experiments, and it was just a group of chemical madmen who made full use of this feature.

Not only did the ingredients and medicinal properties have been quickly studied, but the development of some subsequent drugs has already taken a direction to move forward.

Through a large number of experiments and the powerful analytical tools provided by smart factories, the members of the Fifth Institute learned that the main function of sulfonamide drugs is to inhibit gram-positive bacteria and some negative bacteria. Bacteria that are highly sensitive to them include Streptococcus, pneumococcal, Salmonella, Pneumococcal, and E. coli.

It has an inhibitory effect on Staphylococcus, Bacillus pneumoniae, Pasteuris, Bacillus anthrax, Shigella, Arizona, etc., and also has an effect on certain protozoa that harm poultry.

In a smart factory, using electron microscopes, Duqisheng discovered that the main function of sulfonamides is to inhibit the reproduction of bacteria. Some bacteria need to use para-aminobenzoic acid when they grow. Aminobenzoic acid and dihydropterinyl synthesize dihydrofolic acid under the action of dihydrofolate synthetase.

Under the action of dihydrofolate reductase, dihydrofolate produces tetrahydrofolate, which further forms activated tetrahydrofolate, that is, coenzyme f. It can transmit a carbon group to participate in the synthesis of purine and pyrimidine nucleotides.

Because the chemical structure of sulfonamides is very similar to that of aminobenzoic acid, it can compete with aminobenzoic acid for dihydrofolate synthetase, hinder the formation of dihydrofolate and ultimately affect the synthesis of bacterial riboprotein, thereby inhibiting bacterial growth and reproduction.

This meticulous and realistic observation surprised Du Qisheng. When he returned from Germany, he found Yi Zhongming, who was also a talented chemistry company. He also thought that the research facilities in Qingzhu Chemical were already the most advanced chemical laboratory in the country.

Unexpectedly, in the sub-space, he saw the most advanced instruments in the world. And all the incredible things made this scientific and technological worker who was obsessed with chemistry research deeply feel. Therefore, Du Qisheng focused more on his own work and devoted himself to chemistry research.

Today, Du Qisheng is no longer a subordinate of Yi Zhongming, but has become a member of the Guwen Association and exists as an important scientist. He not only enjoys huge patent dividends, but also has improved his status. If it weren't for the establishment of the rank system, Du Qisheng's contribution would be enough to win the title.

Not only Du Qisheng, but many members of the Fifth Institute have made great contributions, especially in the drug properties testing of "sulfonamide". The entire scientific and technological research and development system of the Guwen Society is a complete organizational structure, with clear division of labor among the members, which is more professional and efficient.

After some efforts, bacteria that are sensitive to sulfonamides can be resistant to both inside and outside the body. After resistance to one sulfonamide, they often develop cross-resistance to other sulfonamides, but bacteria that are resistant to sulfonamides are still sensitive to other antibacterial drugs.

In later generations, in the small medicine box provided by the family, sulfonamide can be regarded as an important member of the permanent troops. When people have inflammation, such as urethritis, enteritis, and respiratory diseases, they often think of "take some sulfonamide".

Indeed, sulfonamide has the advantages of fast effect, accurate efficacy and low price in the treatment of inflammation. However, compared with other drugs, sulfonamide is a medicine with more "contraindications", and once these "contraindications" are ignored, you will have more illnesses and troubles.

When taking ordinary drugs on a daily basis, people generally know that they should drink a large glass of water to take the medicine smoothly, but when taking sulfonamide, it is not something that can be beaten with a large glass of water. However, since the solubility of sulfonamide drugs in the urine is very small, in order to increase their solubility, the best way is to drink as much water as possible, so as to reduce the concentration of drugs in the urine by increasing the amount of urine.

Otherwise, the drug will easily form crystals in the renal tubules, renal pelvis, ureters, bladder, etc., and eventually it may cause side effects such as low back pain, hematuria, urinary tract obstruction, and urinary closure due to its mechanical stimulation. Therefore, if you want to achieve better and faster results, you should try to drink as much water as possible and urinate more while taking the medicine.

In order to prevent stones caused by long-term use of sulfonamide, taking sodium bicarbonate at the same time is also a good way. Adding sodium bicarbonate can not only alkalize the urine and enhance the efficacy of sulfonamide, but also prevent the crystallization of sulfonamide drugs in the urine that may occur after long-term use of sulfonamide.

In addition to growing into small stones in the body, taking sulfonamide may also cause you to be poisoned by accident. Some patients think that sulfonamide is effective and often take two more tablets on their own, or take two more days, thinking that this can consolidate the efficacy of the drug, but the consequences of doing so may lead to accumulated poisoning of the drug. Therefore, during the medication period, patients should not increase the dosage at will, increase the number of times or extend the course of treatment. It is best not to take the medicine for more than 5 days to prevent the side effects of the drug from aggravating the toxicity of the drug.

In addition, one thing to note is that sulfonamide allergy is prone to fixed drug rashes in certain parts such as redness and blisters in the genitals. Because sulfonamide drugs can inhibit the growth of E. coli and hinder the synthesis of B vitamins in the intestines, if you need to take sulfonamide drugs for more than a week, you should take B vitamins at the same time to avoid nutritional deficiency.

However, sulfonamide is forbidden to treat rickettsia disease because it can promote the growth of rickettsia and is not conducive to the disease.

Chemical drugs are not watermelons. Eating too much will only cause diarrhea. If you don’t pay attention to it during the treatment, good medicines will also become poisons. Therefore, Zhong Yang and Yi Zhongming are both very cautious about the market launch of Western medicines such as "sulfonamide", and even can be said to be conservative.

According to Smith's point of view, to be rough, it means that you don't make money and you are purely stupid.

Anyway, the British people have no relatives with Zhong Yang, and Guwenhui is too lazy to care about the lives and deaths of those people. The medical accident caused by "sulfonamide" has nothing to do with Qingzhu Chemical. The only thing that has something to do with Yi Zhongming is the profit of product sales.

As for Du Qisheng, he cared more about his research progress. In order to be able to "study" in the sub-space, he even gave up the 90-year-old patent fee. All of this money was donated to the Issue Fund under the Guwen Society.

In order to produce "sulfonamide" in large quantities and supply "priority" to the markets in Western Europe and North America, Qingzhu Chemical had to urgently become a large-scale pharmaceutical manufacturer specializing in the production of "sulfonamide" and subsequent product research and development. As for why it should provide "priority" to the foreign market?

It is mainly to save the precious lives of fellow compatriots on earth. As for the possibility that it is to conduct a large number of free clinical experiments, using the lives of white friends as reference data for medicinal properties, this is definitely a rumor. With Zhong Yang's kind, innocent and romantic personality, how could he do such cruel things?...

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