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Chapter 729: One word, one dead end

Inside the First Research Building, Lahar also learned about Xu Qiu's news.

But he didn't pay too much attention.

The surgery competition itself is his weakness, and the current scientific research competition is the real focus.

The scientific research projects given by the Bean Guo Medical Research Institute are almost at the limit of existing scientific and technological power, and it is difficult to lose.

He didn't take Xu Qiu seriously at all.

"Come on."

Lahar's attention returned to the laboratory and focused again.

...

Today, Xu Qiu's energy was also focused on the preparation of a fully magnetic levitated artificial heart.

"The flow rate of the artificial heart pump needs to be controlled at 0~10l per minute, and the head is 80 to 120mmhg..."

"In terms of hemolysis performance, nih should be less than about 0.008g per 100l!"

During the research these days, Xu Qiu also obtained more data.

When red blood cells are subjected to shear stress of 0~150pa, they will gradually turn from ellipsoids into elongated ellipsoids. As long as the exposure time is not long, when the shear stress is removed, red blood cells will return to normal shape.

However, as long as it exceeds 150pa, the incidence of hemolysis will greatly increase.

As for more than 1000pa, severe hemolysis will erupt within a few milliseconds.

Based on various data, the preliminary design has been finalized.

The artificial heart has three subjects.

One is the impeller part.

In traditional impeller structure, since the blades will rotate at high speed, red blood cells are exposed to shear stress, and the chance of hemolysis is very high...

Therefore, Xu Qiu led his team to study the influence of factors such as blade curvature, open impeller and blade outlet width on shear stress, and finally screened out that the logarithmic spiral blades had the lowest hemolysis value.

After four months of hard work, the preliminary work has been completed, and the six-blade spiral structure won with the smallest stagnation area, the lowest stress level and the highest strain rate.

Of course, these are just for Miaoyou’s staff.

In fact, after Xu Qiu's design and improvement, the twelve blade pump has more stable performance under high-speed rotation...

...

The second point is the design and structure of the volute part.

Volute shells are the most important overflow component in centrifugal pumps.

Xu Qiu selected circular sections from dozens of volute sections and introduced a brand new architecture, volute sections.

This device can improve the efficiency of the pump.

Of course, all this is based on the heart with a perfect impeller structure.

Xu Qiu’s real result is a fully magnetic levitation heart.

And this technology was split into another experimental team by Xu Qiu. Until now, the two teams did not know that what they were studying was actually the same thing...

“It’s done.”

Two weeks later, on a calm afternoon, Xu Qiu gradually removed the mechanical bearings, sealing rings, valves and other parts in the heart pump.

He uses the magnetic coupling driving method to arrange the driving magnets and secondary driving magnets in the radial direction, and the driving magnets are driven by the motor. By using the magnetic coupling to transmit torque, the driven magnets that receive magnetic force begin to drive the impeller to rotate.

At this point, a generation of fully magnetic levitated artificial hearts have been launched.

...

"Then there is non-invasive prenatal testing method!"

Xu Qiu had already planned this scientific research project.

Compared with the other nine projects, its importance is unmatched.

It is suitable for all human beings. Once successful, the prenatal testing process may be changed in the future, with a profound impact.

From the very beginning, Xu Qiu targeted PCR technology.

During this process, Xu Qiu accidentally discovered the fetal nucleated cells in the maternal circulation.

The other staff were extremely excited.

There are genetic signals in nucleated cells. If the nucleated cells can be analyzed, they will naturally be perfectly competent for non-invasive prenatal testing...

However, Xu Qiu was keenly aware that this was a dead end and cut off this road directly.

Until many years later, when the country of Berry picked up nucleated cells again when trying to find a new method of non-invasive prenatal testing under Xu Qiu's numerous secrets.

It took them seven years and hundreds of billions to finally find out the problem-

This fetal cell is too rare to obtain reliable and consistent signals!

This means that it is not applicable to all clinical mothers, and it is not easy to find nucleated cells that belong to the circulating fetus from the maternal cycle. Even if it can be done, the cost is extremely high.

Seven years later, the scientific research community of Benefits realized how important scientific research talents are. Xu Qiu's casual words made Daxia medical care less waste hundreds of billions and saved nearly seven years of time!

...

After the nucleated cells were denied, Xu Qiu and his team fell into a period of confusion for several weeks.

Blindly searching, no goal.

What inspired Xu Qiu was cancer cells.

As we all know, cancer cells release DNA into the plasma and serum of cancer patients.

Even tiny cancer cells can release DNA, but there is no reason why a huge fetus can not leak at all.

Therefore, Xu Qiu began to look for blood cells.

This is much easier than cancer cells, and pregnant women have DNA fragments of fetal hiding in their blood.

Although the fetal DNA in the mother will disappear immediately within two hours after delivery, this does not affect the application of prenatal diagnosis to it.

After nearly half a month of history, Xu Qiu finally found the extraction method.

He took out the free fetal DNA and then heated the plasma. During this period, all the proteins that would affect the DNA test results were inactivated. Then, in the steps of centrifugation, extraction, etc., the DNA sample obtained finally successfully detected the fetal DNA from the maternal plasma!

This method of extracting fetal DNA through the peripheral blood of pregnant women for non-invasive prenatal diagnosis only requires blood drawing, which is extremely safe, and adopts a new generation of DNA sequencing technology. With the assistance of PCR, even trace amounts of DNA fragments can obtain enough genetic information to accurately complete biological analysis and determine whether the fetus suffers from three major chromosomal diseases.

It is extremely safe and has an accuracy rate of more than 99%.

Compared with amniotic fluid puncture commonly used in clinical practice, it can be said to be a comprehensive advantage.

It can be foreseen that when the peripheral blood extraction fetal DNA technology for pregnant women is released, the world will be shocked, and obstetric prenatal testing in obstetrics and gynecology will also enter a new era...

...

Then, there is a new sequential ventilation therapy.

This is the experience Xu Qiu has explored and summarized after dealing with a huge number of acute lung injuries and pulmonary embolisms and other acute respiratory system diseases, which has also increased the clinical treatment rate by a large margin.

In particular, the proposal of the "pulmonary infection window" will become a key node for invasive and non-invasive treatment, further guiding clinical rescue and treatment.
Chapter completed!
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